Y Wang, J Ye, X Liu, Z Zhang, F Shang, X Qi, Y Zhang, J Du, H Sun, J Xu, H Chen*, M Yu*, S Le*, Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline isomerization,  Nature Communications 16(1):2771(2025)

Y Zhang, Z Zhang, H Sun, Z Xue, Y Wang, Z Guo, S Le*, & H Chen*, Anomalous Force-Dependent Transition Rates Unveil Dual Pathways in Folding and Unfolding Dynamics of Acyl-coenzyme A Binding Protein, The Journal of Physical Chemistry Letters 16, 2479-2486 (2025)

Z Xue, P Yu, Y Zhang, Z Zhang, H Sun, Z Hou, H Hong, S Le*, & H Chen*, Effect of ssDNA ligand in modulating the folding and unfolding dynamics of cold shock protein BcCsp, Physical Review E 111 (1), 014413 (2025)

Y. Zhang#, J. Du#, X. Liu, F. Shang, Y. Deng, J. Ye, Y. Wang, J.Yan, H. Chen*, M. Yu* & S. Le*, Multi-domain interaction mediated strength-building in human α-actinin dimers unveiled by direct single-molecule quantification, Nature Communications 15: 6151 (2024) 

J. Xu, H. Sun, Z. Zhang, Z. Guo, S. Le*, H. Chen* , Folding and Misfolding Dynamics of Irisin Protein Revealed by Single-Molecule Magnetic Tweezers  , The Journal of Physical Chemistry Letters 15, 11954-11960 (2024)

S. Le#, M. Yu#, C. Fu#, JA Heier, S Martin, J. Hardin*, J. Yan* , Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1 during mechanotransduction , Proceedings of the National Academy of Sciences 121 (37), e2400654121 (2024) 

 Y Sun, X Liu, W Huang, S Le, J Yan*, Structural domain in the Titin N2B-us region binds to FHL2 in a force-activation dependent manner, Nature Communications 15 (1), 4496 (2024)

Z Xue, H Sun, H Hong, Z Zhang, Y Zhang, Z Guo, S Le*, H Chen*, Comparative analysis of folding and unfolding dynamics and free-energy landscapes in homologous cold shock proteins with variable thermal stabilities, Physical Review Research 6 (2), 023170 (2024)

W. Huang*, J. Liu, S. Le, M. Yao, Y. Shi, J. Yan*, In situ single-molecule investigations of the impacts of biochemical perturbations on conformational intermediates of monomeric α-synuclein, APL bioengineering 8(1):016114, (2024)

L. Yuan, H. Sun, X. Ma, Y. Wang, Z. Guo, X. Qi, S. Le*, H. Chen*, Ligand-dependent folding and unfolding dynamics and free energy landscapes of acylphosphatase. Soft Matter 20 (18), 3780-3786 (2024). 

Y. Zhou, X. Zhao, Y. Jiang, D. J. Lin, C. Lu, Y. Wang, S. Le, R. Li, and J. Yan*, A Mechanical Assay for the Quantification of Anti-RBD IgG Levels in Finger-Prick Whole Blood.  ACS Sens., online (2023).

J. Liu, S. Le, M. Yao, W. Huang, Z. Tio, Y. Zhou, and J. Yan*,  Tension Gauge Tethers as Tension Threshold and Duration Sensors. ACS Sens., 8(2): 704–711 (2023).

W. Huang, S. Le, Y. Sun, DJ Lin, M, Yao, Y. Shi, J. Yan*, Mechanical Stabilization of a Bacterial Adhesion Complex. J. Am. Chem. Soc., 144(37):16808-16818 (2022) 

M. Yu, J. Lu, S. Le*, and J. Yan*, Unexpected Low Mechanical Stability of Titin I27 Domain at Physiologically Relevant Temperature, J. Phys. Chem. Lett., 12(33), 7914-7920  (2021) 

S. Le, M. Yu, and J. Yan*, Mechanical Regulation of Tension-transmission Supramolecular Linkages. Curr. Opin. Solid State Mater. Sci., 25:100895 (2021). 

T. Nguyen, S. Le, M. Lee, J.S. Fan, D. Yang, J. Yan, and G .Jedd*, Fungal Wound Healing through Instantaneous Protoplasmic Gelation, Curr Biol., 31(2):271-282.e5 (2021) 

Y. Wang, M. Yao, K. Baker, R. Gough, S Le, B. Goult* and J. Yan*, Force-Dependent Interactions between Talin and Full-Length Vinculin. J. Am. Chem. Soc.,143(36):14726-14737 (2021).

M. Yu, Z. Zhao, Z. Chen, S. Le*, and J. Yan*, Modulating Mechanical Stability of Heterodimerization Between Engineered Orthogonal Helical Domains, Nat. Commun., 11: 4476 (2020) 

M. Yu#, S. Le#, S. Barnett#, Z. Guo, X. Zhong, P. Kanchanawong*, and J. Yan*,  Implementing Optogenetic Modulation in Mechanotransduction, Phys. Rev. X, 10, 021001 (2020) 

S. Le, M. Yu, A. Bershadsky*, and J.Yan*, Mechanical regulation of formin-dependent actin polymerization. Semin. Cell Dev. Biol., 102: 73-80 (2020).

S. Le#, M. Yu#, and J. Yan*, Direct Single-molecule Quantification Reveals Surprisingly High Mechanical Stability of Vinculin--Talin/alpha-Catenin Linkages, Sci. Adv., 5 (12), eaav2720 (2019) 

S. Le#, M. Yu#, and J. Yan*, Phosphorylation Reduces the Mechanical Stability of alpha-catenin/beta-catenin Complex, Angew. Chem. Int. Ed, 58(51) 18663-18669 (2019) 

M. Yu#, S. Le#, Y. Ammon#, B. Goult, A. Akhmanova*, and J. Yan*, Force-dependent Regulation of KANK1-talin Complex at Focal Adhesions, Nano Lett., 19 (9), 5982-5990 (2019)

S. Pang#, S. Le#, A. Kwiatkowski, and J. Yan*, Mechanical Stability of alphaT-catenin and its Activation by Force for Vinculin Binding, Mol. Biol. Cell, 30(16):1930-1937 (2019) 

C. Lu, S. Le, J. Chen, A. Byrd, D. Rhodes, K. Raney, and J. Yan*, Direct quantification of the translocation activities of Saccharomyces cerevisiae Pif1 helicase, Nucleic Acids Res., 47(14):7494-7501 (2019) 

X. Zhao, S. Guo, J. Chen, C. Lu, S. Le, H. Fu and J. Yan*,  Single-molecule manipulation quantification of site-specific DNA binding. Curr. Opin. Chem. Biol. 53, 106-117 (2019). 

S. Le, M. Yu, L. Hovan, Z. Zhao, J. Ervasti, and J. Yan*, Dystrophin as a Molecular Shock Absorber, ACS Nano, 12(12):12140-12148 (2018) 

M. Yu#, S. Le#, A. Efremov, X. Zeng, A. Bershadsky, and J. Yan*, Effects of Mechanical Stimuli on Profilin- and Formin-mediated Actin Polymerization, Nano Lett.,18 (8), 5239-5247. (2018) 

S. Pang#, S. Le#, and J. Yan*, Mechanical responses of the mechanosensitive unstructured domains in cardiac titin, Biol. Cell, 110(3):65-76. (2018).

S. Guo#, Q. Tang#, M. Yao, H. You, S. Le, H. Chen, and J. Yan*, Structural-elastic determination of the force-dependent transition rate of biomolecules, Chem. Sci., 9(27):5871-5882 (2018).

H. You#, S. Guo#, S. Le, M. Yao, H. Chen, and J. Yan*, Two-State folding energy determinationbased on transition points in nonequilibriumsingle-molecule experiments, J. Phys. Chem. Lett., 9(4) 811-816 (2018). 

S. Le, X. Hu, M. Yao, H. Chen, M. Yu, X. Xu, F. Margadant, M. Sheetz*, and J. Yan*, Mechanotransmission and Mechanosensing of Human alpha-actinin 1, Cell Reports., 21, 1-10. (2017) 

D. Spadaro, S. Le, T. Laroche, I. Mean, L. Jond, J. Yan and S. Citi*, Tension-dependent stretching activates ZO-1 to control the junctional localization of its interactors, Curr Biol., 27, 1-13 (2017) 

G. Yuan, S. Le, M. Yao, H. Qian, X. Zhou, J. Yan*, and H. Chen*, Elasticity of transition state leads to an unexpected mechanical stabilization of titin immunoglobulin domains. Angew. Chem. Int. Ed. Engl., 56(20):5490-5493 (2017).

S. Le#, E. Serrano#, R. Kawamura B. Carrasco, J. Yan*, and J.Alonso*, Bacillus Subtilis DprA and SsbA Promote the Assembly of a RecA Nucleoprotein Filament that Can Overcome RecX Inhibition during Natural Chromosomal Transformation, Nucleic Acids Res., 45(15): 8873-8885 (2017) 

J. Chen, Q. Tang S. Guo, C. Lu, S. Le, J. Yan*, Parallel triplex structure formed between stretched single-stranded DNA and homologous duplex DNA, Nucleic Acids Res., 45(17): 10032-10041 (2017)

M. Yu#, X.Yuan#, C. Lu, S. Le, R. Kawamura, A. Efremov, Z. Zhao, M. Kozlov, M. Sheetz, A. Bershadsky*, and J.Yan*,  mDia1 senses both force and torque during F-actin filament polymerization, Nat. Commun., 8: 1650 (2017).

S. Le, R. Liu, C. T. Lim*, and J. Yan*, Uncovering Mechanosensing Mechanisms at the Single Protein Level using Magnetic Tweezers. Methods, 94:13-8. (2016).

S. Le#, M. Yao#, J. Chen, A. K. Efremov, S. Azimi, and J. Yan*, Disturbance-free Rapid Solution Exchange for Magnetic Tweezers Single-molecule Studies, Nucleic Acids Res., 43(17): e113 (2015) 

J. Chen#, S. Le#, A. Basu, W. J. Chazin*, and J. Yan*,  Mechanochemical regulations of RPA's binding to ssDNA. Sci. Rep.,19,5:9296 (2015).

S. Le, H. Chen, X. Zhang, J. Chen, K. Patil, K. Muniyappa*, and J. Yan*, Mechanical Force Antagonizes the Inhibitory Effects of RecX on RecA Filaments Formation in M. tuberculosis, Nucleic Acids Res. 42 (19): 11992-11999. (2014) 

H. Fu#, S. Le#, H. Chen, K. Muniyappa*, and J. Yan*, Force and ATP Hydrolysis Dependent Regulation of RecA Nucleoprotein Filament by Single-stranded DNA Binding Protein, Nucleic Acids Res., 41, 924 (2013) 

S. Le, H. Chen, P. Cong, J. Lin, P. Droge, and J. Yan*, Mechanosensing of DNA bending in a single specific protein-DNA complex. Sci. Rep., 3-3508 (2013).

H. Fu#, S. Le#, K. Muniyappa*, and J. Yan*, Dynamics and Regulation of RecA polymerization and de-polymerization on double-stranded DNA. PLoS ONE, 8(6): e66712 (2013).

X. Zhang, H. Chen, S. Le, I. Rouzina, P. Doyle* and J. Yan*, Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching by single-molecule calorimetry. Proc. Natl. Acad. Sci. U.S.A.,10.1073 (2013).